Breve descrizione dei contenuti: The scenarios of Ambient Intelligence introduce a new computing paradigm and set new challenges for the design and engineering of secure and dependable sys-tems. This chapter describes SERENITY, a comprehensive approach to overcome those problems. The key to success in this scenario is to capture security expertise in such a way that it can be supported by automated means. SERENITY’s integral model of S&D considers both static and dynamic aspects by relying in two main innovations: (1) the enhanced notion of S&D patterns and integration schemes; and (2) the computer aided run-time monitoring of the implemented security solutions.